技术研发
论文及专利
Publications  论文

(注:标识  为瑞吉科技术团队研发人员)

1.Yan X(徐妍), Ke-Jian Z, Xian-Zhen C, et al. Mapping of cytotoxic T lymphocytes epitopes in E7 antigen of human papillomavirus type 11[J]. Archives for Dermatological Research, 2008, 300(5):235-242.
2.Xu Y(徐妍), Zhu K.‐J, Zhu N, et al. Expression of Foxp3+CD4+CD25+ regulatory T cells and Th1/Th2, Tc1/Tc2 profiles in the peripheral blood of patients with condyloma acuminatum[J]. Clinical & Experimental Dermatology, 2009, 34(2):229-235.
3.Chen X. Z, Zhu K. J, Xu Y(徐妍), et al. RNA interference silences the human papillomavirus 6b/11 early gene E7 in vitro and in vivo[J]. Clinical & Experimental Dermatology, 2009, 35(5):509-515.
4.Ke-Jia Zhao, Hao Cheng, Ke-Jian Zhu, Yan Xu(徐妍), Min-li Chen, Xing Zhang, Tao Song, Jun Ye, Qi Wang and Da-Fang Chen Recombined DNA vaccines encoding calreticulin linked to HPV6bE7 enhance immune response and inhibit angiogenic activity in B16 melanoma mouse model expressing HPV 6bE7 antigen. Archives of Dermatological Research .2007. 298(2), 64-72
5.X. Z. Chen, K. J. Zhu, Y. Xu(徐妍), X. Y. Tang, X. Z. Cai, X. Zhang, H. Cheng. RNA interference silences the human papillomavirus 6b/11 early gene E7 in vitro and in vivo. Clinical and Experimental Dermatology. 35(5) 509–515.
7.徐妍, 程浩, 赵可佳,等. 钙网蛋白基因120片段和人乳头瘤病毒6bE7基因诱导的小鼠细胞免疫反应[J]. 中华皮肤科杂志, 2005, 12期:755-758.
8.徐妍, 程浩, 赵可佳,等. 表达CRT/E7融合蛋白的人乳头瘤病毒DNA疫苗对肿瘤生长和血管生成抑制作用的研究[J]. 病毒学报, 2007, 第6期:466-470.
9.徐妍, 程浩, 朱可建,等. 人乳头状瘤病毒11型E7抗原HLA-A*0201限制性细胞毒性T淋巴细胞表位的功能鉴定[J]. 中华微生物学和免疫学杂志, 2008, 28:239-243.
10.Jinlong Huang, Shukui Wang, Cui Wei(魏翠), Yan Xu(徐妍), Ying Wang, Jiyang Jin , Gaojun Teng.  In vivo differentiation of adipose-derived stem cells in an injectable poloxamer-octapeptide hybrid hydrogel. [J]. Tissue and Cell. 43 (2011) 344–349.
11.黄金龙, 徐妍, 魏翠,等. 自体脂肪源性干细胞在面部整形美容中的应用[J]. 中国美容整形外科杂志, 2011, 22:650-652.
12.Biao Sun, Shilei Guo(郭世磊), Fei Xu, Bin Wang, Xiujuan Liu, Yuanyuan Zhang, Yan Xu(徐妍). Concentrated Hypoxia-preconditioned adipose mesenchymal stem-cell conditioned medium improves wounds healing on skin full thick defect model. International Scholar Research Notices, vol.2014, 652713. 
13.Yang Xu, JA Zhang, Yan Xu(徐妍), Shilei Guo(郭世磊), S Wang, Di Wu, Ying Wang, Dan Luo, Bingrong Zhou. Antiphotoaging Effect of Conditioned Medium of Dedifferentiated Adipocytes on Skin In Vivo and In Vitro: A Mechanistic Study. Stem Cells Dev. 2014 Dec 17.
14.Bing-Rong Zhou,Yang Xu,Shi-Lei Guo(郭世磊),Yan Xu(徐妍),Ying Wang,Fen Zhu,Felicia Permatasari, Di Wu, Zhi-Qiang Yin, andDanLuo.The Effect of Conditioned Media of Adipose-Derived Stem Cells on Wound Healing after Ablative Fractional Carbon Dioxide Laser Resurfacing.BioMed Research International.2013,519126.
15.Shilei Guo(郭世磊), Zhiying Zhang, Yan Xu(徐妍), Yunxia Zhi, Changjie Han, Yuhao Zhou, Fang Liu, Haiyan Lin, Chuansen Zhang. Bone marrow-derived, neural-like cells have the characteristics of neurons to protect the peripheral nerve in micro-environment. Stem Cells International, 2015, 941625.
16.黄金龙, 董运海, 魏翠,等. 复合水凝胶负载人脂肪间充质干细胞体内分化的研究[J]. 中国美容整形外科杂志, 2010, 第11期:650-653.
17.程飞飞, 魏翠, 潘文雯,等. 去分化脂肪细胞的生物学特性探究[J]. 中国美容整形外科杂志, 2012, 23.
18.Zhang X F, Chen L(陈蕾), Yang Q F, et al. Spectroscopic and molecular modeling study of cyanine dye interacting with human serum transferrin[J]. Colloids & Surfaces A Physicochemical & Engineering Aspects, 2015, 469:187–193.
19.Zhang Xiu‐feng, Chen Lei(陈蕾), Yang Qian‐fan, et al. Study on the interaction of a cyanine dye with human serum transferrin[J]. Luminescence, 2015.

20.Lei Chen (陈蕾), Shilei Guo (郭世磊), Cui Wei (魏翠), Honglan Li (李红兰), Haiya Wang (王海亚), Yan Xu (徐妍). Effect of Stem Cell Transplantation on Premature Ovarian Failure in Vitro and in Vivo: A Meta Analysis and Case Report. Experimental and Therapeutic Medicine, 2016.


Patents  专利
细胞运输及人体输注装置(下图一)
一种修复皮肤损伤和皮肤护理的细胞因子冷敷系统(下图二)
人脐带间充质干细胞复合细胞因子在制备修复皮肤损伤的生物制剂中的应用(下图三)
永生化人肺微血管内皮细胞复合细胞因子在制备组织缺血损伤修复药物中的应用(实质审查)

一种辅助免疫细胞疗法的靶向纳米载药体系及其制备方法(实质审查)
用于预防宫腔粘连及子宫内膜损伤修复的细胞制剂及其制备方法(申请中)



图一:细胞运输及人体输注装置 专利证书
图二:一种修复皮肤损伤和皮肤护理的细胞因子冷敷系统 专利证书


图三:人脐带间充质干细胞复合细胞因子在制备修复皮肤损伤的生物制剂中的应用 专利证书